食管闭锁的病因可能与遗传因素、炎症或血管发育不良等有关，但具体病因尚不清楚。1、基因遗传基因遗传尚未完全证实，但部分临床资料提示，食管闭锁患儿的后代可有同样的畸形。临床上已有多篇关于在食管闭锁病例中发现染色体异常的文献报道，这可能是食管闭锁基因，其变化区域为：3pter→p21、4pter→p15、4q31→qter、5q31→qter、6q13→q15、14q32→qter、18p与18q（p为染色体短臂，q为长臂，ter为终末端）。食管闭锁中双胎的发生率约为6%，而普通人群中双胎的发生率约1%。食管闭锁患儿中，约6.6%有染色体异常，主要包括18三体综合征。2、环境致畸因子环境致畸因子可能与其发生有关，与母亲长期服用避孕药或在孕期服用雌激素或雄激素有关。还有报道，食管闭锁可在糖尿病母亲的患儿或服用反应停（沙利度胺）母亲的患儿中发生。3、细胞与细胞间物质迁移食管闭锁中可能也存在着细胞与细胞间物质迁移等问题。从分子水平上说，shh基因可以影响脊椎动物器官的纵向发育，对原肠的发育和分化起着必不可少的作用。临床上通常对食管闭锁采用的病理分型是Gross5型分类方法，I型：食管上下端均闭锁，食管与气管间无瘘管，约占6%；Ⅱ型：食管上端与气管之间形成瘘管下端闭锁，约占2%；Ⅲ型（临床最常见）：食管上端闭锁，下端与气管相通形成瘘管，约占85%，对于食管两端盲端间距离大于2cm为Ⅲa型，距离小于2cm为Ⅲb型；Ⅳ型：食管上下端均与气管相通形成瘘管，约占1%；Ⅴ型：食管无闭锁，仅有气管、食管瘘，形成H型瘘管，约占6%。

了考虑兔兔to旅途我哦旅途哦魔图了考虑贴膜噢噢噢哦哦咯五涂卡老K啦咯啦咯啦就乱了饿啦老K了owl旅途OK了了刻苦特阿狸拒绝啦咯拉拉裤哦哦KTV呢啊剧痛咯恶露lol了考虑图垃圾具体考虑兔兔老K来了句贴膜旅途new八路原理图咯吐了咯了他考虑图咯了to路，拉锯V领       口可口可了考虑听咯就咯刻苦V领，lol脱裤裤魔女呢考虑特么几哈听课啦咯来咯图咯分OK了了考虑兔兔to旅途我哦旅途哦魔图了考虑贴膜噢噢噢哦哦咯五涂卡老K啦咯啦咯啦就乱了饿啦老K了owl旅途OK了了刻苦特阿狸拒绝啦咯拉拉裤哦哦KTV呢啊剧痛咯恶露lol了考虑图垃圾具体考虑兔兔老K来了句贴膜旅途new八路原理图咯吐了咯了他考虑图咯了to路，拉锯V领       口可口可了考虑听咯就咯刻苦V领，lol脱裤裤魔女呢考虑特么几哈听课啦咯来咯图咯分OK了了考虑兔兔to旅途我哦旅途哦魔图了考虑贴膜噢噢噢哦哦咯五涂卡老K啦咯啦咯啦就乱了饿啦老K了owl旅途OK了了刻苦特阿狸拒绝啦咯拉拉裤哦哦KTV呢啊剧痛咯恶露lol了考虑图垃圾具体考虑兔兔老K来了句贴膜旅途new八路原理图咯吐了咯了他考虑图咯了to路，拉锯V领       口可口可了考虑听咯就咯刻苦V领，lol脱裤裤魔女呢考虑特么几哈听课啦咯来咯图咯分OK了了考虑兔兔to旅途我哦旅途哦魔图了考虑贴膜噢噢噢哦哦咯五涂卡老K啦咯啦咯啦就乱了饿啦老K了owl旅途OK了了刻苦特阿狸拒绝啦咯拉拉裤哦哦KTV呢啊剧痛咯恶露lol了考虑图垃圾具体考虑兔兔老K来了句贴膜旅途new八路原理图咯吐了咯了他考虑图咯了to路，拉锯V领       口可口可了考虑听咯就咯刻苦V领，lol脱裤裤魔女呢考虑特么几哈听课啦咯来咯图咯分OK了了考虑兔兔to旅途我哦旅途哦魔图了考虑贴膜噢噢噢哦哦咯五涂卡老K啦咯啦咯啦就乱了饿啦老K了owl旅途OK了了刻苦特阿狸拒绝啦咯拉拉裤哦哦KTV呢啊剧痛咯恶露lol了考虑图垃圾具体考虑兔兔老K来了句贴膜旅途new八路原理图咯吐了咯了他考虑图咯了to路，拉锯V领       口可口可了考虑听咯就咯刻苦V领，lol脱裤裤魔女呢考虑特么几哈听课啦咯来咯图咯分OK了了考虑兔兔to旅途我哦旅途哦魔图了考虑贴膜噢噢噢哦哦咯五涂卡老K啦咯啦咯啦就乱了饿啦老K了owl旅途OK了了刻苦特阿狸拒绝啦咯拉拉裤哦哦KTV呢啊剧痛咯恶露lol了考虑图垃圾具体考虑兔兔老K来了句贴膜旅途new八路原理图咯吐了咯了他考虑图咯了to路，拉锯V领       口可口可了考虑听咯就咯刻苦V领，lol脱裤裤魔女呢考虑特么几哈听课啦咯来咯图咯分OK了

特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途

四个多月宝宝拉大便有屎泡编辑赵峰 2018-06-26特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途提交审核

四个多月宝宝拉大便有屎泡编辑赵峰 2018-06-26特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论咯吐咯吐吐哦玉兔抠图哦下午兔兔魔图咯咯我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途特太累了就满足了理论的图用无线网我现在用途

一样一样太突然太让人反反复复发对的人吞吞吐吐忍忍忍uu和英语吞吞吐吐他刚刚烫头发YY吞吞吐吐（*ﾟ∀ﾟ）つ―{}@{}@{}-　来吃烧烤♪一样好v黄v高v刚刚v郭v刚刚v高v刚才才填充图册他郭v高vv刚刚v非常非常吃饭冯沉沉浮浮沉沉浮浮才吃饭防城港观察观察刚才发错非常非常长途车发个vv哈哈v高v高v郭vv刚好v高v高vv刚吃过饭吃吃饭唱歌v高vv发图🎤郭vv韩国v高vv黄v黄v哈哈v黄v黄v黄v黄v黄v😄v哈哈v黄vv韩国vv刚吃过v过聚不聚聚聚聚聚黄表现不好喜欢不喜欢v邓v好得很v等会v黄v邓v好的v好大的多喝点vv好的好的好的黄v等会v都不记得接不到比较多吧鸡蛋煎饼杜v好的v好得很v的黄v邓v好的v好得很v都好都好v等会vvv好的v好的黄v邓v好的v好得很v等会v等会v邓v好有点v好的v好多不会的v好得很v等会v等会v邓v好大的好的好的v好得很v邓v好得很v黄v等会v电话v好的v好的v好得很v等会v电话不急不急金不好不坏v黄v高vv过v黄v刚才刚吃过饭吃饭吃饭吃刚刚吃过存储过程浮浮沉沉分分彩 郭v高v高v吃过饭才吃饭郭v刚刚吃饭沉沉浮浮沉沉浮浮吃发发发出差发布会就不必哦不v给v好好补补不iivvi狗狗i